Glutaredoxin protects cerebellar granule neurons from dopamine-induced apoptosis by dual activation of the ras-phosphoinositide 3-kinase and jun n-terminal kinase pathways.

Glutaredoxin protects cerebellar granule neurons from dopamine-induced apoptosis by dual activation of the ras-phosphoinositide 3-kinase and jun n-terminal kinase pathways.

Source :

• The Journal of biological chemistry [ 0021-9258 ] ; 2001.

Descripteurs français

• KwdFr :
  • Activation enzymatique (MeSH), Animaux (MeSH), Animaux nouveau-nés (MeSH), Antienzymes (pharmacologie), Apoptose (effets des médicaments et des substances chimiques), Cellules cultivées (MeSH), Cervelet (cytologie), Cervelet (physiologie), Dopamine (pharmacologie), Escherichia coli (MeSH), Facteur de transcription NF-kappa B (métabolisme), Farnésol (analogues et dérivés), Farnésol (pharmacologie), Glutarédoxines (MeSH), JNK Mitogen-Activated Protein Kinases (MeSH), Mitogen-Activated Protein Kinases (métabolisme), Modèles neurologiques (MeSH), Neurones (cytologie), Neurones (effets des médicaments et des substances chimiques), Neurones (physiologie), Oxidoreductases (MeSH), Phosphatidylinositol 3-kinases (métabolisme), Phosphorylation (MeSH), Protein-Serine-Threonine Kinases (MeSH), Protéines (pharmacologie), Protéines G ras (métabolisme), Protéines bactériennes (pharmacologie), Protéines proto-oncogènes (métabolisme), Protéines proto-oncogènes c-akt (MeSH), Salicylates (pharmacologie), Souris (MeSH), Souris de lignée BALB C (MeSH), Système de signalisation des MAP kinases (effets des médicaments et des substances chimiques), Système de signalisation des MAP kinases (physiologie).
• MESH :
  • analogues et dérivés : Farnésol.
  • cytologie : Cervelet, Neurones.
  • effets des médicaments et des substances chimiques : Apoptose, Neurones, Système de signalisation des MAP kinases.
  • métabolisme : Facteur de transcription NF-kappa B, Mitogen-Activated Protein Kinases, Phosphatidylinositol 3-kinases, Protéines G ras, Protéines proto-oncogènes.
  • pharmacologie : Antienzymes, Dopamine, Farnésol, Protéines, Protéines bactériennes, Salicylates.
  • physiologie : Cervelet, Neurones, Système de signalisation des MAP kinases.
  • Activation enzymatique, Animaux, Animaux nouveau-nés, Cellules cultivées, Escherichia coli, Glutarédoxines, JNK Mitogen-Activated Protein Kinases, Modèles neurologiques, Oxidoreductases, Phosphorylation, Protein-Serine-Threonine Kinases, Protéines proto-oncogènes c-akt, Souris, Souris de lignée BALB C.

English descriptors

• KwdEn :
  • Animals (MeSH), Animals, Newborn (MeSH), Apoptosis (drug effects), Bacterial Proteins (pharmacology), Cells, Cultured (MeSH), Cerebellum (cytology), Cerebellum (physiology), Dopamine (pharmacology), Enzyme Activation (MeSH), Enzyme Inhibitors (pharmacology), Escherichia coli (MeSH), Farnesol (analogs & derivatives), Farnesol (pharmacology), Glutaredoxins (MeSH), JNK Mitogen-Activated Protein Kinases (MeSH), MAP Kinase Signaling System (drug effects), MAP Kinase Signaling System (physiology), Mice (MeSH), Mice, Inbred BALB C (MeSH), Mitogen-Activated Protein Kinases (metabolism), Models, Neurological (MeSH), NF-kappa B (metabolism), Neurons (cytology), Neurons (drug effects), Neurons (physiology), Oxidoreductases (MeSH), Phosphatidylinositol 3-Kinases (metabolism), Phosphorylation (MeSH), Protein-Serine-Threonine Kinases (MeSH), Proteins (pharmacology), Proto-Oncogene Proteins (metabolism), Proto-Oncogene Proteins c-akt (MeSH), Salicylates (pharmacology), ras Proteins (metabolism).
• MESH :
  • chemical , analogs & derivatives : Farnesol.
  • chemical , metabolism : Mitogen-Activated Protein Kinases, NF-kappa B, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins, ras Proteins.
  • chemical , pharmacology : Bacterial Proteins, Dopamine, Enzyme Inhibitors, Farnesol, Proteins, Salicylates.
  • cytology : Cerebellum, Neurons.
  • drug effects : Apoptosis, MAP Kinase Signaling System, Neurons.
  • physiology : Cerebellum, MAP Kinase Signaling System, Neurons.
  • Animals, Animals, Newborn, Cells, Cultured, Enzyme Activation, Escherichia coli, Glutaredoxins, JNK Mitogen-Activated Protein Kinases, Mice, Mice, Inbred BALB C, Models, Neurological, Oxidoreductases, Phosphorylation, Protein-Serine-Threonine Kinases, Proto-Oncogene Proteins c-akt.

Abstract

Affiliations:

• Israël

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